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Case Report
Combination of triamcinolone/5FU with multiple Z-plasty: A powerful duo to combat cicatricial ectropion
1 Wahidin Sudirohusodo General Hospital, Makassar, South Sulawesi, Indonesia
2 Department of Ophthalmology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
3 Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Address correspondence to:
Sisca Sisca
Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi,
Indonesia
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Article ID: 100057Z17AP2026
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Pratiwi A, Pagarra H, Amir S, Jaury JV, Sofyan S, Sisca S. Combination of triamcinolone/5FU with multiple Z-plasty: A powerful duo to combat cicatricial ectropion. J Case Rep Images Opthalmol 2026;9(2):17–22.ABSTRACT
Introduction: Cicatricial ectropion, a condition characterized by eyelid malposition and conjunctival exposure, can result from trauma, scarring, or surgical interventions. Management requires a personalized approach, as various treatments show limited succes when used alone.
Case Report: A 43-year-old patient presented with severe cicatricial ectropion. Examination showed significant keloid traction along the upper and lower eyelid margin and an extensive hypertrophic scar extending from the lower eyelid to the cheek. A combination of intralesional injections of 5-fluorouracil (5-FU) triamcinolone acetonide (TA) was administered in four cycles. This was followed by surgical correction using multiple Z-plasty on the lower eyelid. Postoperatively, no ectropion remained, and favorable results were noted six months later with no significant side effects.
Conclusion: The combination of 5-FU and TA, followed by Z-plasty, provides an effective and promising approach for treating severe cicatricial ectropion. This method improves scar reduction and skin pliability, offering functional and aesthetic benefits with minimal complications compared to traditional treatments like skin grafting.
Keywords: Cicatricial ectropion, Eyelid surgery, 5-Fluorouracil, Scar management, Triamcinolone acetonide, Z-plasty
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Acknowledgments
Artificial Intelligence (AI) Disclosure
The authors declare that this manuscript was prepared entirely without the use of generative AI.
Andi Pratiwi - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Halimah Pagarra - Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Suliati Amir - Acquisition of data, Analysis of data, Drafting the article, Final approval of the version to be published
Junely Vimala Jaury - Substantial contributions to conception and design, Interpretation of data, Drafting the article, Final approval of the version to be published
Syukriah Sofyan - Analysis of data, Revising it critically for important intellectual content, Final approval of the version to be published
Sisca Sisca - Substantial contributions to conception and design, Interpretation of data, Drafting the article, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2026 Andi Pratiwi et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
