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Case Report
Focal laser and intravitreal bevacizumab for choroidal neovascularization secondary to Grönblad–Strandberg syndrome
1 FRCSEd, FWACS, DRCOphth, MSc, Clinical Research Consultant Ophthalmologist, Retinal Unit, Eye Foundation Hospital, 27 Issac John Street, Ikeja GRA, Lagos, Nigeria
2 FWACS, FMCOph, Consultant Ophthalmologist, Retinal Unit, Eye Foundation Hospital, 27 Issac John Street, Ikeja GRA, Lagos, Nigeria
Address correspondence to:
Toyin Akanbi
Retinal Unit, Eye Foundation Hospital, 27 Isaac John Street, Ikeja GRA, Lagos,
Nigeria
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Article ID: 100036Z17OO2023
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Oderinlo O, Akanbi T. Focal laser and intravitreal bevacizumab for choroidal neovascularization secondary to Grönblad–Strandberg syndrome. J Case Rep Images Opthalmol 2023;6(1):5–8.ABSTRACT
Introduction: Pseudoxanthoma elasticum is a rare genetic disorder. It has several ocular features including angioid streaks and choroidal neovascularization which can significantly affect vision.
Case Report: A 50-year-old man presented with nine months history of poor vision affecting both distant and near vision. His best corrected visual acuities were 6/18 right eye and 1/60 left eye. His anterior segments were normal. Funduscopy revealed linear hyperpigmented irregular branching peripapillary lesions; angioid streaks both eyes. He had bilateral speckled retina pigment epithelial hyperpigmented lesions interspaced with dot hemorrhages in the macula region suggestive of likely choroidal neovascularization. He had “peau d’orange” skin appearance around his neck. Fundus fluorescein angiography showed features of occult subfoveal choroidal neovascularization. He was referred to a physician and had a skin biopsy which revealed histologic features of Pseudoxanthoma elasticum. He was treated with bilateral focal argon laser. However he had right intravitreal Bevacizumab after a large ipsilateral subfoveal hemorrhage. His visual acuities remained stable afterward.
Conclusion: Patients with Pseudoxanthoma elasticum have to be closely monitored for ocular manifestations. Choroidal neovascularization should be detected early and promptly treated. Antivascular endothelial growth factor injections have become the preferred treatment option for choroidal neovascularization in these patients.
Keywords: Bevacizumab, Choroidal neovascularization, Laser, Pseudoxanthoma elasticum
SUPPORTING INFORMATION
Author Contributions
Olufemi Oderinlo - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Toyin Akanbi - Substantial contributions to conception and design, Acquisition of data, Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2023 Olufemi Oderinlo et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
